期刊
BRAIN IMAGING AND BEHAVIOR
卷 5, 期 1, 页码 25-35出版社
SPRINGER
DOI: 10.1007/s11682-010-9108-x
关键词
Arterial spin-labeled perfusion MRI; Pharmacologic MRI; Dementia with Lewy bodies; Cholinesterase inhibitors
类别
资金
- National Institute of Neurological Disorders and Stroke [F32NS047431]
- National Institute on Aging [K23AG031320, K24AG000949, RO1AG19599]
- Alzheimer's Association [IIRG-08-88737]
- Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife
- Pfizer/Eisai, Inc.
Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls underwent arterial spin-labeled perfusion MRI (ASL-pMRI) and neuropsychological testing. Patterns of cerebral blood flow (CBF) and cognitive performance were compared. In addition, combined ASL-pMRI and ChEI drug challenge (pharmacologic MRI) was tested as a probe of cholinergic function in 4 of the DLB participants. Frontal and parieto-occipital hypoperfusion was observed in both DLB and AD but was more pronounced in DLB. Following ChEI treatment, perfusion increased in temporal and parieto-occipital cortex, and cognitive performance improved on a verbal fluency task. If confirmed in a larger study, these results provide further evidence for brain cholinergic dysfunction in DLB pathophysiology, and use of pharmacologic MRI as an in vivo measure of cholinergic function.
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