期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 39, 期 -, 页码 75-79出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2014.01.004
关键词
Exercise immunology; Thymus; Naive T cell
资金
- EU FP6 project Allostem
- University of Edinburgh
Athletes undergoing intensive training schedules have chronic exposure to stress-induced hormones such as cortisol that can depress immune function. We compared the circulating levels of T cell receptor excision circles (TREC), a marker of recent thymic emigrants, as well as the levels of naive and memory subsets in a group of elite endurance athletes and in controls. The athletes showed a reduction in absolute numbers of naive T cells, particularly in CD4 T cells. In contrast, memory cells were increased. TREC levels in the athletes were significantly reduced compared to age-matched controls. Such changes resemble premature ageing of the T cell component of the immune system. Since thymic production of T cells naturally decline with age, these results raise the concern that prolonging high intensity exercise into the 4th decade of life may have deleterious consequences for athletes' health. (C) 2014 Elsevier Inc. All rights reserved.
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