High dietary protein restores overreaching induced impairments in leukocyte trafficking and reduces the incidence of upper respiratory tract infection in elite cyclists

The present study examined whether a high protein diet prevents the impaired leukocyte redistribution in response to acute exercise caused by a large volume of high-intensity exercise training. Eight cyclists (VO2max: 64.2 +/- 6.5 mL kg(-1) min(-1)) undertook two separate weeks of high-intensity training while consuming either a high protein diet (3 g kg(-1) protein BM-1 day(-1)) or an energy and carbohydrate-matched control diet (1.5 g kg(-1) protein BM-1 day(-1)). High-intensity training weeks were preceded by a week of normal-intensity training under the control diet. Leukocyte and lymphocyte sub-population responses to acute exercise were determined at the end of each training week. Self-reported symptoms of upper-respiratory tract infections (URTI) were monitored daily by questionnaire. Undertaking high-intensity training with a high protein diet restored leukocyte kinetics to similar levels observed during normal-intensity training: CD8(+) TL mobilization (normal-intensity: 29,319 +/- 13,130 cells/mu L x similar to 165 min vs. high-intensity with protein: 26,031 +/- 17,474 cells/mu L x similar to 165 min, P > 0.05), CD8(+) TL egress (normal-intensity: 624 +/- 264 cells/mu L vs. high-intensity with protein: 597 +/- 478 cells/mu L, P > 0.05). This pattern was driven by effector-memory populations mobilizing (normal-intensity: 6,145 +/- 6,227 cells/mu L x similar to 165 min vs. high-intensity with protein: 6,783 +/- 8,203 cells/mu L x similar to 165 min, P > 0.05) and extravastating from blood (normal-intensity: 147 +/- 129 cells/mu L vs. high-intensity with protein: 165 +/- 192 cells/mu L, P > 0.05). High-intensity training while consuming a high protein diet was associated with fewer symptoms of URTI compared to performing high-intensity training with a normal diet (P < 0.05). To conclude, a high protein diet might reduce the incidence of URTI in athletes potentially mediated by preventing training-induced impairments in immune-surveillance. (C) 2013 Elsevier Inc. All rights reserved.