期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 26, 期 7, 页码 1095-1101出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2012.07.006
关键词
Meditation; Mindfulness; Older adults; Aging; Loneliness; Genetics; Gene expression; Stress
资金
- National Institutes of Health [R01-AG034588, R01-AG026364, R01-119159, R01-HL079955, R01-MH091352]
- Cousins Center for Psychoneuroimmunology at UCLA
- Inflammatory Biology Core Laboratory of the UCLA Claude D. Pepper Older Americans Independence Center
- National Institute of Aging [5P30 AG028748]
- UCLA Social Genomics Core Laboratory [P30-AG107265]
- Pittsburgh Life Sciences Greenhouse Opportunity Fund
Lonely older adults have increased expression of pro-inflammatory genes as well as increased risk for morbidity and mortality. Previous behavioral treatments have attempted to reduce loneliness and its concomitant health risks, but have had limited success. The present study tested whether the 8-week Mindfulness-Based Stress Reduction (MBSR) program (compared to a Wait-List control group) reduces loneliness and downregulates loneliness-related pro-inflammatory gene expression in older adults (N = 40). Consistent with study predictions, mixed effect linear models indicated that the MBSR program reduced loneliness, compared to small increases in loneliness in the control group (treatment condition x time interaction: F(1,35) = 7.86, p = .008). Moreover, at baseline, there was an association between reported loneliness and upregulated pro-inflammatory NF-kappa B-related gene expression in circulating leukocytes, and MBSR downregulated this NF-kappa B-associated gene expression profile at post-treatment. Finally, there was a trend for MBSR to reduce C Reactive Protein (treatment condition x time interaction: (F(1,33) = 3.39, p = .075). This work provides an initial indication that MBSR may be a novel treatment approach for reducing loneliness and related pro-inflammatory gene expression in older adults. (c) 2012 Elsevier Inc. All rights reserved.
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