期刊
ANALYTICAL CHEMISTRY
卷 87, 期 21, 页码 10668-10678出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b01543
关键词
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资金
- NSF Career Award
- Cottrell Scholar Award
- Sloan Research Fellow Award
- Indiana University Quantitative Chemical Biology
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1518379] Funding Source: National Science Foundation
Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the expected fragmentation patterns for many scaffolds is limited, further complicating analysis. Here, we summarize advances in natural product structure elucidation based upon the application of collision induced dissociation fragmentation mechanisms.
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