期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 25, 期 4, 页码 640-646出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2010.12.020
关键词
Inflammation; C-reactive protein; Saliva; Biomarker; Enzyme-linked immunoassay (ELISA)
资金
- Department of Health via the National Institute of Health Research (NIHR)
- Institute of Psychiatry at King's College London, UK
- Canadian Institutes of Health Research
- NARSAD
- UK Department of Health
- ESRC [ES/H034897/1] Funding Source: UKRI
- MRC [G9806489, G1002190] Funding Source: UKRI
- Economic and Social Research Council [ES/H034897/1] Funding Source: researchfish
- Medical Research Council [G1002190, G9817803B, G9806489] Funding Source: researchfish
- National Institute for Health Research [CSA/01/05/001] Funding Source: researchfish
This study aimed to validate a high-sensitivity assay for C-reactive protein (CRP) in saliva as an alternative medium to study inflammation in large epidemiological cohorts and young people. We measured CRP in saliva and serum in 61 (29.5% males) healthy adult volunteers. We found a moderate-to-strong association between CRP measured in saliva and in serum (r = .72, p < .001). In agreement with the non-steroidal structure and the high molecular weight of CRP, we observed a low saliva-to-serum CRP ratio (1:1633.64). Furthermore, a dichotomous index of salivary CRP, equivalent to a clinically relevant serum CRP cut-off (3 mg/l), was associated to known correlates of systemic inflammation (IL-6, BMI and smoking). Finally, we showed that CRP in saliva is stable at room temperature up to 8 h after collection. Our study provides initial evidence suggesting that non-invasive assessment of CRP in saliva allows valid prediction of serum CRP. Salivary CRP may thus facilitate and promote research exploring the correlates of low-grade inflammation in epidemiological studies and makes it feasible to expand psychoneuroimmunology research to pediatric populations. (C) 2011 Elsevier Inc. All rights reserved.
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