期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 24, 期 8, 页码 1347-1353出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2010.06.013
关键词
Seasonal allergic rhinitis (SAR); Hypothalamus-pituitary-adrenal (HPA) axis; Stress; Chronic (allergic) inflammation; Cortisol
Previously we could demonstrate attenuated responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to stress in patients with chronic allergic inflammatory disease (i e, atopic dermatitis, allergic asthma) The present study was designed to investigate HPA axis function in an acute manifestation of allergy. Patients with seasonal allergicihinitis(SAR, n = 20)and non-atopic controls (n = 20)were exposed to a standardized laboratory stressor (Trier Social Stress Test'. TSST) Cortisol responses to the TSST and cortisol awakening responses (CAR) were measured in SAR subjects while suffering from acute symptoms of SAR (pollen season), and during a non-active state of their disease (pollen-free season) To assess the acuity and severity of SAR, eosinophil and basophil numbers and SAR symptomatology were determined Non-allergic control subjects were examined at identical times during the year To control for possible sequence effects, a cross-over design was used SAR patients showed significantly increased symptom seventy (t = 9 4, p < 001)as well as eosinophil (F(1, 31) = 9 8, p < 01) and basophil (F(1, 38) = 6 4, p < 05) numbers during the pollen season when compared to a pollen-free period When exposed to the TSST. significantly attenuated cortisol responses were found in SAR subjects during acute manifestation of the disease (pollen season) when compared to the pollen-free season (F(16, 456) = 1.65, p < 05) In SAR patients, there was a significant negative col relation between symptom severity and the cortisol response to the stressor (r = 53. p < 05) No significant between-group or between-condition differences with respect to the CAR could be determined (all p > 05) These findings support previous data of attenuated HPA axis responsiveness to stress in atopic conditions and further, suggest that HPA axis hyporesponsiveness in atopy may be linked to the severity of the allergic inflammatory process (C) 2010 Elsevier Inc All rights reserved
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