期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 24, 期 8, 页码 1231-1240出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2010.06.014
关键词
Cervical cancer; Healing Touch; Complementary and alternative medicine; Psychoneuroimmunology; Relaxation; NK cell cytotoxicity
资金
- NIH [R21AT0095801, P20AT75601]
- National Center for Research Resources, NIH [UL1RR024979]
Patients receiving chemoradiation for cervical cancer are at risk for distress, chemoradiation-related side-effects. and immunosuppression This prospective randomized clinical trial examined effects of a complementary therapy, Healing Touch (HT), versus relaxation training (RT) and usual care (UC) for (1) supporting cellular immunity, (2) improving mood and quality of life (QOL.), and (3) reducing treatment-associated toxicities and treatment delay in cervical cancer patients receiving chemoradiation Sixty women with stages IBI to IVA cervical cancer were randomly assigned to receive UC or 4x/weekly individual sessions of either HT or RT immediately following radiation during their 6-week chemoradiation treatment Patients completed psychosocial assessments and blood sampling before chemoradiation at baseline, weeks 4 and 6 Multilevel regression analyses using orthogonal contrasts tested for differences between treatment conditions over time. HT patients had a minimal decrease in natural killer cell cytotoxicity (NKCC) over the course of treatment whereas NKCC of RI and UC patients declined sharply during chemoradiation (group by time interaction p = 0.018). HT patients showed greater decreases in two different indicators of depressed mood (CES-D depressed mood subscale and POMS depression scale) compared to RI and UC (group by time interactions p < 0.05) No between group differences were observed in QOL, treatment delay, or clinically-rated toxicities HT may benefit cervical cancer patients by moderating effects of chemoradiation on depressed mood and cellular immunity Effects of HT on toxicities, treatment delay. QOL,. and fatigue were not observed. Long-term clinical implications of findings are not known (C) 2010 Elsevier Inc All rights reserved
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