期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 24, 期 4, 页码 525-528出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2009.10.015
关键词
Dopamine; Immunity; T cells; Dendritic cells; Macrophages; NK cells; B cells; Microglia
资金
- DRDO Government of India [LSRB/24/EPB/2001]
- Council of Scientific and Industrial Research Government of India [9/30(43)/2005-EMR-1]
- National Institutes of Health, USA [CA118265, CA124763]
- Department of Defense, USA [W81XWH-07-1-0051]
- NATIONAL CANCER INSTITUTE [R21CA118265, R01CA124763] Funding Source: NIH RePORTER
The neurotransmitter dopamine (DA) is an important molecule bridging the nervous and immune systems. DA through autocrine/paracrine manner modulates the functions of immune effector cells by acting through its receptors present in these cells. DA also has unique and opposite effects on T cell functions. Although DA activates naive or resting T cells, but it inhibits activated T cells. In addition, changes in the expression of DA receptors and their signaling pathways especially in T cells are associated with altered immune functions in disorders like schizophrenia and Parkinson's disease. These results suggest an immunoregulatory role of DA. Therefore, targeting DA receptors and their signaling pathways in these cells by using DA receptor agonists and antagonists may be useful for the treatment of diseases where DA induced altered immunity play a pathogenic role. (C) 2009 Elsevier Inc. All rights reserved.
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