期刊
BREAST CANCER RESEARCH
卷 13, 期 6, 页码 -出版社
BMC
DOI: 10.1186/bcr2905
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资金
- Terry Fox Foundation
- Canadian Institutes of Health Research
- Canadian Cancer Society
- Canadian Breast Cancer Research Alliance
- US Department of Defense
- National Institutes of Health
Consistent with their essential role in cell adhesion to the extracellular matrix, integrins and their associated signaling pathways have been shown to be involved in cell proliferation, migration, invasion and survival, processes required in both tumorigenesis and metastasis. beta 1-integrins represent the predominantly expressed integrins in mammary epithelial cells and have been proven crucial for mammary gland development and differentiation. Here we provide an overview of the studies that have used transgenic mouse models of mammary tumorigenesis to establish beta 1-integrin as a critical mediator of breast cancer progression and thereby as a potential therapeutic target for the development of new anticancer strategies.
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