期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 23, 期 2, 页码 251-256出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2008.09.015
关键词
beta(2)-integrin; Stress; Negative affect; Adrenergic reactivity; Inflammation; Cardiovascular disease risk
资金
- NHLBI NIH HHS [R01 HL067459] Funding Source: Medline
Adhesion of circulating monocytes to the vascular endothelium is one of the earliest steps in the development of atherosclerosis. This leukocyte-to-endothelium interaction is mediated in part by beta(2)-integrins, a group of cell adhesion molecules that bind to endothelial ligands. Given the significance of this interaction to atherogenesis, we examined the effects of stress, operationalized as the arousal of negative affect (NA) and cardiovascular and catecholamine responses to the Anger Recall Interview (ARI), on the expression of LFA-1 (CD11a), Mac-1 (CD11b) and p150/95 (CD11c) on circulating monocytes (CD14+). Subjects were 173 healthy, nonsmoking men and women (60% men, 40% minorities, aged 18-49 year). Arousal of NA, cardiovascular responses (heart rate [HR], systolic blood pressure [SBP], diastolic blood pressure [DBP]), circulating catecholamines (epinephrine [Epi], norepinephrine [Nel) and beta(2)-integrin (CD11/CD18) expression were determined prior to and following the ARL The principal findings were that the ARI, on average, induced a decrease in monocyte expression Of beta(2)-integrins. However, after adjusting for age, sex, body mass index, exercise status, and baseline level Of beta(2)-integrin expression, those individuals who showed the largest increases in NA, Ne and DBP during the ARI showed an increase in monocyte beta(2)-integrin expression. Thus, heightened psychological and physiological stress responses induced phenotypic changes in monocytic expression Of beta(2)-integrins that are consistent with the role of monocytes/macrophages in vascular inflammation and increased risk of atherosclerotic cardiovascular disease. (C) 2008 Elsevier Inc. All rights reserved.
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