期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 22, 期 2, 页码 140-147出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2007.08.011
关键词
innate immunity; toll-like receptors; CNS; glial cells; astrocytes; microglia; autoimmunity; neurotoxicity; cytokines
资金
- NIAID NIH HHS [T32 AI060523] Funding Source: Medline
- NINDS NIH HHS [P01 NS023349-210008, P01 NS023349, F31 NS048807, P01 NS023349-21] Funding Source: Medline
Innate immunity in the CNS depends primarily on the functions of glial cells, astrocytes and microglia, which are important for the early control of pathogen replication and direct the recruitment and activation of cells of the adaptive immune system required for pathogen clearance. Efficient immune responses are required for clearance of an invading pathogen, but dysregulation of a pro-inflammatory response in the CNS could lead to the development of autoimmunity. This review summarizes the activation of toll-like receptors (TLRs) expressed on glial cells and the functional outcome of these interactions for CNS health and disease which depends on a delicate balance of the protective and toxic effects of molecules induced in the CNS following TLR ligation. (C) 2007 Elsevier Inc. All rights reserved.
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