期刊
BRAIN AND LANGUAGE
卷 133, 期 -, 页码 26-38出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2014.03.007
关键词
Common marmoset; Language; Specific language impairment; Dyslexia; Vocal communication; Gene expression
资金
- Japan Society for the Promotion of Science (JSPS) [21700294, 23700317]
- Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)
- Center for Advanced Research on Logic and Sensibility
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [21700294, 25118002, 23700317] Funding Source: KAKEN
Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder-(FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular Mechanisms underlying language impairments. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
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