期刊
BRAIN AND LANGUAGE
卷 126, 期 1, 页码 99-108出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2012.06.010
关键词
Thalamus; Language; Learning; Memory; Pulvinar; Ventral thalamic nuclei; Deep brain stimulation; Basal ganglia; Neostriatum; Long-term potentiation
Regionalization of language function within the left thalamus has been established with language and verbal memory effects of thalamic stimulation during surgery for movement disorders. Three distinct language effects of thalamic stimulation were established: anomia from posterior ventrolateral (VL) and pulvinar regions; perseveration from mid-VL regions; and, a memory and acceleratory effect from anterior VL, described as a specific alerting response (SAR). These studies are reviewed in context of pertinent contemporary and recent literature on the thalamic role in memory and language. An explicit mechanistic model for the anomia and SAR effect is proposed. The suggested model for the SAR effect involves secondary switching in the striatum by the activation of thalamostriatal projections, whereas the anomia effect implicates the disruption of the cortical synchronization action of pulvinar via the cortico-pulvinar-cortical projection system. Further experimental data is required to firmly establish these mechanisms. (c) 2012 Elsevier Inc. All rights reserved.
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