期刊
BRAIN AND LANGUAGE
卷 126, 期 1, 页码 73-88出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2012.06.011
关键词
Thalamus; Language; Aphasia; Basal ganglia
资金
- Department of Veterans Affairs Rehabilitation Research and Development Service [B6364L]
- National Institute on Deafness and Other Communication Disorders [R21 DC009247]
Recent literature on thalamic aphasia and thalamic activity during neuroimaging is selectively reviewed followed by a consideration of recent anatomic and physiological findings regarding thalamic structure and functions. It is concluded that four related corticothalamic and/or thalamocortical mechanisms impact language processing: (1) selective engagement of task-relevant cortical areas in a heightened state of responsiveness in part through the nucleus reticularis (NR), (2) passing information from one cortical area to another through corticothalamo-cortical mechanisms, (3) sharpening the focus on task-relevant information through corticothalamo-cortical feedback mechanisms, and (4) selection of one language unit over another in the expression of a concept, accomplished in concert with basal ganglia loops. The relationship and interaction of these mechanisms is discussed and integrated with thalamic aphasia and neuroimaging data into a theory of thalamic functions in language. Published by Elsevier Inc.
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