期刊
BRAIN AND LANGUAGE
卷 121, 期 1, 页码 47-57出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2012.02.005
关键词
fMRI; Speech production; Parietal lobe; Independent component analysis
资金
- Medical Research Council [MC_U120064975] Funding Source: Medline
- MRC [MC_U120064975] Funding Source: UKRI
- Medical Research Council [MC_U120064975] Funding Source: researchfish
- National Institute for Health Research [ACF-2008-21-038] Funding Source: researchfish
This functional MRI study investigated the involvement of the left inferior parietal cortex (IPC) in spoken language production (Speech). Its role has been apparent in some studies but not others, and is not convincingly supported by clinical studies as they rarely include cases with lesions confined to the parietal lobe. We compared Speech with non-communicative repetitive tongue movements (Tongue). The data were analyzed with both univariate contrasts between conditions and probabilistic independent component analysis (ICA). The former indicated decreased activity of left IPC during Speech relative to Tongue. However, the ICA revealed a Speech component in which there was correlated activity between left IPC, frontal and temporal cortices known to be involved in language. Therefore, although net synaptic activity throughout the left IPC may not increase above baseline conditions during Speech, one or more local systems within this region are involved, evidenced by the correlated activity with other language regions. (C) 2012 Elsevier Inc. All rights reserved.
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