期刊
BRAIN AND LANGUAGE
卷 120, 期 3, 页码 237-250出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2011.11.003
关键词
Primary progressive aphasia; Semantic interference; Word interference paradigms; Naming deficits in primary progressive aphasia; FreeSurfer; Cortical thickness
资金
- NIH [RO1DC01948]
- Alzheimer's Disease Core Center, Northwestern University [AG13854]
- Center for Advanced MRI (CAMRI) at Northwestern University
- [R01DC008551]
This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n = 17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0 ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0 ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000 ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients. (C) 2011 Elsevier Inc. All rights reserved.
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