期刊
BRAIN AND COGNITION
卷 77, 期 3, 页码 327-334出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandc.2011.09.002
关键词
Consciousness; Responsiveness; Subjective experiences; Depth of sedation; Dexmedetomidine
资金
- Academy of Finland [8110957, 8111818, 8124623]
- Signe and Ane Gyllenberg Foundation
- National Graduate School of Psychology in Finland
Anesthetic-induced changes in the neural activity of the brain have been recently utilized as a research model to investigate the neural mechanisms of phenomenal consciousness. However, the anesthesiologic definition of consciousness as responsiveness to the environment seems to sidestep the possibility that an unresponsive individual may have subjective experiences. The aim of the present study was to analyze subjective reports in sessions where sedation and the loss of responsiveness were induced by dexmedetomidine, propofol, sevoflurane or xenon in a nonsurgical experimental setting. After regaining responsiveness, participants recalled subjective experiences in almost 60% of sessions. During dexmedetomidine sessions, subjective experiences were associated with shallower depth of sedation as measured by an electroencephalography-derived anesthesia depth monitor. Results confirm that subjective experiences may occur during clinically defined unresponsiveness, and that studies aiming to investigate phenomenal consciousness under sedative and anesthetic effects should control the subjective state of unresponsive participants with post-recovery interviews. (C) 2011 Elsevier Inc. All rights reserved.
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