期刊
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
卷 33, 期 1, 页码 46-48出版社
ELSEVIER INC
DOI: 10.1016/S1701-2163(16)34772-7
关键词
Benzodiazepine; teratogenicity; malformation risk
资金
- Research Leadership for Better Pharmacotherapy During Pregnancy and Lactation
Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.
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