期刊
NEFROLOGIA
卷 31, 期 5, 页码 560-566出版社
SOC ESPANOLA NEFROLOGIA DR RAFAEL MATESANZ
DOI: 10.3265/Nefrologia.pre2011.Jul.10834
关键词
Cysta tin C; Microalbuminuria; Glomerular filtration rate; Chronic kidney disease; Hypertension; Diabetes; Hyperlipidemia
Background: The aim of this study was to assess serum cystatin C and urinary albumin in the early detection of impairment in cardiovascular and renal function. Material and methods: Cystatin C was quantified in sera from healthy people, moreover, cystatin C was quantified in a group of patients diagnosed with chronic kidney disease for predicting a measured glomerular filtration rate <60 ml/min/1.73 m(2). Finally serum cysta tin C and microalbuminuria were measured in patients with increasing of risk of impairment in cardiovascular and renal function (hypertension, diabetes and hyperlipidemia). Results: When the serum cystatin C was quantified in a group of risk, we observe as when being increased the cystatin C, the values of the glomerular filtration rate decreased (p <0.05), the cystatin values C were increased when increasing the age of the patients (p <0.05) and cystatin C values higher than 0.95 mg/l were not observed in patient smaller than 50 years old. In the group of risk, serum cystatin C was high regarding to the values obtained in healthy people in 27.6%, microalbuminuria in the 20.3% and both parameters were high in the 14.4% of patients with a glomerular filtration rate >90 ml/min/1.73 m(2), while in patients with a glomerular filtration rate 60-90 ml/min/1.73 m(2), cystatin C was high in the 51.7% and the microalbuminuria only in the 6.4%. Conclusions: Determinations of serum cystatin C associated to the quantification of urinary albumin in patients with cardiovascular risk can optimize the early detection of vascular and renal damage. Cysta tin C can show vascular and renal damage in patients without urinary albumin.
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