期刊
BRAIN & DEVELOPMENT
卷 32, 期 4, 页码 293-298出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2009.03.008
关键词
Numb; Asymmetric cell division; Cancer
Numb carries the distinction of being the first molecule discovered to influence cell fate by being asymmetrically segregated during cell division. Originally identified from Studies in Drosophila, further work has since demonstrated the importance of Numb in mammalian and, in particular, human systems, from diverse fields such as developmental neurobiology to cancer biology and neurodegenerative disease. This review Surveys the body of knowledge concerning Numb, and discusses the relevance of Numb to human biology and disease. (C) 2009 Elsevier B.V. All rights reserved.
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