期刊
FRONTIERS IN NEUROSCIENCE
卷 5, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fnins.2011.00025
关键词
aging; processing speed; cerebellum; prefrontal; source based morphometry
资金
- National Institute on Deafness and other Communication Disorders [P50 DC00422]
- Research Facilities Improvement Program from the National Center for Research Resources [C06 RR14516]
Processing speed, or the rate at which tasks can be performed, is a robust predictor of age-related cognitive decline and an indicator of independence among older adults. This review examines evidence for neurobiological predictors of age-related changes in processing speed, which is guided in part by our source based morphometry findings that unique patterns of frontal and cerebellar gray matter predict age-related variation in processing speed. These results, together with the extant literature on morphological predictors of age-related changes in processing speed, suggest that specific neural systems undergo declines and as a result slow processing speed. Future studies of processing speed - dependent neural systems will be important for identifying the etiologies for processing speed change and the development of interventions that mitigate gradual age-related declines in cognitive functioning and enhance healthy cognitive aging.
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