期刊
BRAIN
卷 138, 期 -, 页码 483-497出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awu360
关键词
transcranial magnetic stimulation; electroencephalography; schizophrenia; obsessive-compulsive disorder; dorsolateral prefrontal cortex; coritcal inhibition; gamma oscillations
资金
- Ontario Mental Health Foundation (OMHF) research studentship
- OMHF
- NHMRC [606907]
- Cervel Neurotech
- Brainsway Inc
- Sepracor Inc
- AstraZeneca
- Eli Lilly
- Ontario Mental Health Foundation (OMHF)
- Canadian Institutes of Health Research (CIHR)
- Brain and Behaviour Research Foundation
- Temerty Family through the Centre for Addiction and Mental Health (CAMH) Foundation
- Grant Family through the Centre for Addiction and Mental Health (CAMH) Foundation
- Campbell Institute
Abnormal gamma-aminobutyric acid inhibitory neurotransmission is a key pathophysiological mechanism underlying schizophrenia. Transcranial magnetic stimulation can be combined with electroencephalography to index long-interval cortical inhibition, a measure of GABAergic receptor-mediated inhibitory neurotransmission from the frontal and motor cortex. In previous studies we have reported that schizophrenia is associated with inhibitory deficits in the dorsolateral prefrontal cortex compared to healthy subjects and patients with bipolar disorder. The main objective of the current study was to replicate and extend these initial findings by evaluating long-interval cortical inhibition from the dorsolateral prefrontal cortex in patients with schizophrenia compared to patients with obsessive-compulsive disorder. A total of 111 participants were assessed: 38 patients with schizophrenia (average age: 35.71 years, 25 males, 13 females), 27 patients with obsessive-compulsive disorder (average age: 36.15 years, 11 males, 16 females) and 46 healthy subjects (average age: 33.63 years, 23 females, 23 males). Long-interval cortical inhibition was measured from the dorsolateral prefrontal cortex and motor cortex through combined transcranial magnetic stimulation and electroencephalography. In the dorsolateral prefrontal cortex, long-interval cortical inhibition was significantly reduced in patients with schizophrenia compared to healthy subjects (P = 0.004) and not significantly different between patients with obsessive-compulsive disorder and healthy subjects (P = 0.5445). Long-interval cortical inhibition deficits in the dorsolateral prefrontal cortex were also significantly greater in patients with schizophrenia compared to patients with obsessive-compulsive disorder (P = 0.0465). There were no significant differences in long-interval cortical inhibition across all three groups in the motor cortex. These results demonstrate that long-interval cortical inhibition deficits in the dorsolateral prefrontal cortex are specific to patients with schizophrenia and are not a generalized deficit that is shared by disorders of severe psychopathology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据