相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Enhanced Proteolytic Clearance of Plasma Aβ by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain Aβ in Mice
John R. Walker et al.
JOURNAL OF NEUROSCIENCE (2013)
Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease
Fredrik Jeppsson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
Natalia N. Nalivaeva et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Treatment Strategies Targeting Amyloid β-Protein
Dale Schenk et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
Robert Tamayev et al.
EMBO JOURNAL (2011)
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Eric Karran et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Sink Hypothesis and Therapeutic Strategies for Attenuating Aβ Levels
Yan Zhang et al.
NEUROSCIENTIST (2011)
Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease
Brian Spencer et al.
PLOS ONE (2011)
A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
Hiroaki Fukumoto et al.
JOURNAL OF NEUROSCIENCE (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Suppression of Amyloid Deposition Leads to Long-Term Reductions in Alzheimer's Pathologies in Tg2576 Mice
Rachel A. Karlnoski et al.
JOURNAL OF NEUROSCIENCE (2009)
Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease
Salim S. El-Amouri et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Clearance of amyloid-β by circulating lipoprotein receptors
Abhay Sagare et al.
NATURE MEDICINE (2007)
Reducing amyloid plaque burden via ex vivo gene delivery of an aβ-degrading protease:: A novel therapeutic approach to Alzheimer!Disease
Matthew L. Hemming et al.
PLOS MEDICINE (2007)
Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-β peptide in vivo
C-S Hong et al.
GENE THERAPY (2006)
Anti-A beta(42)- and anti-A beta(40)-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
Y Levites et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
IgG-assisted age-dependent clearance of Alzheimer's amyloid β peptide by the blood-brain barrier neonatal Fc receptor
R Deane et al.
JOURNAL OF NEUROSCIENCE (2005)
Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease
TA Comery et al.
JOURNAL OF NEUROSCIENCE (2005)
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-β peptide in mouse brain
N Iwata et al.
JOURNAL OF NEUROSCIENCE (2004)
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
DM Wilcock et al.
JOURNAL OF NEUROSCIENCE (2004)
RAGE (Yin) versus LRP (Yang) balance regulates Alzheimer amyloid β-peptide clearance through transport across the blood-brain barrier
R Deane et al.
STROKE (2004)
Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
MA Leissring et al.
NEURON (2003)
Kinetics of amyloid β-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays
MA Leissring et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
R Deane et al.
NATURE MEDICINE (2003)
Peptidases, proteases and amyloid beta-peptide catabolism
LB Hersh
CURRENT PHARMACEUTICAL DESIGN (2003)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier
F Schlachetzki et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
RB DeMattos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
K Shirotani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Metabolic regulation of brain Aβ by neprilysin
N Iwata et al.
SCIENCE (2001)
Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier
Y Zhang et al.
JOURNAL OF NEUROIMMUNOLOGY (2001)
Augmented senile plaque load in aged female β-amyloid precursor protein-transgenic mice
MJ Callahan et al.
AMERICAN JOURNAL OF PATHOLOGY (2001)
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid β peptide in the brain
Y Takaki et al.
JOURNAL OF BIOCHEMISTRY (2000)
Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
M Shibata et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
F Bard et al.
NATURE MEDICINE (2000)
Clearance of amyloid β-peptide from brain:: transport or metabolism?: Reply
N Iwata et al.
NATURE MEDICINE (2000)