期刊
BRAIN
卷 136, 期 -, 页码 2677-2696出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awt210
关键词
Alzheimer's disease; microglia; immunotherapy; innate immunity; clinical trial
资金
- Alzheimer Research UK [ART/PG2006/4, ART-EXT2010-1]
- Medical Research Council [G0501033]
- Alzheimers Research UK [ART-PG2006-4, ART-ESG2005-3] Funding Source: researchfish
- Medical Research Council [G0501033, MC_PC_14095] Funding Source: researchfish
- MRC [MC_PC_14095, G0501033, G0701018, G1100578] Funding Source: UKRI
Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-beta immunotherapy. We investigated the expression of multiple inflammatory markers in the brains of 28 non-immunized patients with Alzheimer's disease and 11 patients with Alzheimer's disease immunized against amyloid-beta(42) (AN1792): microglial ionized calcium-binding adaptor Iba-1, lysosome marker CD68, macrophage scavenger receptor A, Fc gamma receptors I (CD64) and II (CD32); and also immunoglobulin IgG, complement C1q and the T lymphocyte marker CD3 using immunohistochemistry. The data were analysed with regard to amyloid-beta and phospho-tau pathology, severity of cerebral amyloid angiopathy and cortical microhaemorrhages. In non-immunized Alzheimer's disease cases, amyloid-beta(42) correlated inversely with CD32 and Iba-1, whereas phospho-tau correlated directly with all microglial markers, IgG, C1q and the number of T cells. In immunized Alzheimer's disease cases, amyloid-beta(42) load correlated directly with macrophage scavenger receptor A-positive clusters and inversely with C1q. The severity of cerebral amyloid angiopathy and microhaemorrhages did not relate to any of the analysed markers. Overall, the levels of CD68, macrophage scavenger receptor A, CD64, CD32 and the number of macrophage scavenger receptor A-positive plaque-related clusters were significantly lower in immunized than non-immunized cases, although there was no significant difference in Iba-1 load, number of Iba-1-positive cells, IgG load, C1q load or number of T cells. Our findings indicate that different microglial populations co-exist in the Alzheimer's disease brain, and that the local inflammatory status within the grey matter is importantly linked with tau pathology. After amyloid-beta immunization, the microglial functional state is altered in association with reduced amyloid-beta and tau pathology. The results suggest that, in the long term, amyloid-beta immunotherapy results in downregulation of microglial activation and potentially reduces the inflammation-mediated component of the neurodegeneration of Alzheimer's disease.
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