3.9 Article

STUDIES TOWARDS THE N-ACYLATIVE KINETIC RESOLUTION OF NOBIN

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出版社

INST ORGANIC CHEM AND BIOCHEM
DOI: 10.1135/cccc2011034

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Kinetic resolution; Atropisomerism; Asymmetric synthesis; Organocatalysis

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  1. Engineering and Physical Sciences Research Council [GR/S04284/01] Funding Source: researchfish

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An investigation into the N-acylation of atropisomeric anilines 8 and 2, which are related to NOBIN (1), catalysed by small molecule chiral pyridine-based nucleophilic catalysts is described. The first organocatalytic kinetic resolution (KR) of an atropisomeric aniline is described.

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