期刊
BRAIN
卷 135, 期 -, 页码 1578-1585出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/aws066
关键词
brain circuits; cerebral ischaemia; visual system; dorsal stream; neurological disorders
资金
- Bundesministerium fur Bildung und Forschung (BMBF-Verbund) [01GW0654]
- National Institutes of Health [R01EY019477]
A fundamental aspect of visual cognition is our disposition to see the 'forest before the trees'. However, damage to the posterior parietal cortex, a critical brain region along the dorsal visual pathway, can produce a neurological disorder called simultanagnosia, characterized by a debilitating inability to perceive the 'forest' but not the 'trees' (i.e. impaired global processing despite intact local processing). This impairment in perceiving the global shape persists even though the ventral visual pathway, the primary recognition pathway, is intact in these patients. Here, we enabled global processing in patients with simultanagnosia using a psychophysical technique, which allowed us to bias stimuli such that they are processed predominantly by the intact ventral visual pathway. Our findings reveal that the impairment in global processing that characterizes simultanagnosia stems from a disruption in the processing of low-spatial frequencies through the dorsal pathway. These findings advance our understanding of the relationship between visuospatial attention and perception and reveal the neural mechanism mediating the disposition to see the 'forest before the trees'.
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