期刊
BRAIN
卷 133, 期 -, 页码 2136-2147出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awq130
关键词
partial epilepsy; genome-wide association; genetics; common variants
资金
- Medical Research Council [G0400126]
- Wellcome Trust [084730]
- UCLH CRDC [F136]
- National Institute for Health Research [08-08-SCC]
- National Society for Epilepsy
- Department of Health's NIHR Biomedical Research Centres
- Irish patient cohort was supported by the Irish Higher Education Authority [PRTLI3]
- Science Foundation Ireland [08/RFP/GEN1538]
- GlaxoSmithKline
- Funds National de la Recherche Scientifique [FC 63574/3.4.620.06 F]
- Fondation Erasme
- Universite Libre de Bruxelles
- Muscular Dystrophy Association, USA
- Irish Institute of Clinical Neurosciences
- National Institutes of Health, USA
- MRC [G0400126, G0000934, G9805989] Funding Source: UKRI
- Science Foundation Ireland (SFI) [08/RFP/GEN1538] Funding Source: Science Foundation Ireland (SFI)
- Medical Research Council [G9805989, G0000934, G0400126] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10161] Funding Source: researchfish
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio < 1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.
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