期刊
BRAIN
卷 132, 期 -, 页码 2839-2849出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awp202
关键词
brain metabolism; C-13-labelling; microdialysis; NMR; traumatic brain injury (human)
资金
- The Canadian Institute of Health Research, the Medical Research Council [G9439390, ID 65883, G0600986, ID79068]
- Academy of Medical Sciences/Health Foundation
- MRC ( Acute Brain Injury Programme Grant)
- National Institute for Health Research Biomedical Research Centre, Cambridge
- The Evelyn Trust
- Academy of Medical Sciences/ Health Foundation Senior Surgical Scientist Fellowship
- Medical Research Council [G0600986, G9439390] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
- MRC [G9439390, G0600986] Funding Source: UKRI
Energy metabolism in the human brain is not fully understood. Classically, glucose is regarded as the major energy substrate. However, lactate (conventionally a product of anaerobic metabolism) has been proposed to act as an energy source, yet whether this occurs in man is not known. Here we show that the human brain can indeed utilize lactate as an energy source via the tricarboxylic acid cycle. We used a novel combination of C-13-labelled cerebral microdialysis both to deliver C-13 substrates into the brain and recover C-13 metabolites from the brain, and high-resolution C-13 nuclear magnetic resonance. Microdialysis catheters were placed in the vicinity of focal lesions and in relatively less injured regions of brain, in patients with traumatic brain injury. Infusion with 2-C-13-acetate or 3-C-13-lactate produced C-13 signals for glutamine C4, C3 and C2, indicating tricarboxylic acid cycle operation followed by conversion of glutamate to glutamine. This is the first direct demonstration of brain utilization of lactate as an energy source in humans.
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