期刊
BRAIN
卷 132, 期 -, 页码 843-852出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awp011
关键词
conduct problems; callousunemotional traits; orbitofrontal cortex; anterior cingulate cortex; voxel-based morphometry
资金
- Medical Research Council (UK) [G0401170]
- Department of Health Forensic Mental Health Programme [MRD 12-73]
- Medical Research Council PhD studentship
- National Institute for Health Research Postdoctoral Fellowship Award
- Royal Society Wolfson Merit Award
- National Institute for Health Research Biomedical Research Centre South London
- Maudsley NHS Foundation Trust/Institute of Psychiatry (King's College London)
- Medical Research Council [G0401170] Funding Source: researchfish
- MRC [G0401170] Funding Source: UKRI
Brain imaging studies of adults with psychopathy have identified structural and functional abnormalities in limbic and prefrontal regions that are involved in emotion recognition, decision-making, morality and empathy. Among children with conduct problems, a small subgroup presents callousunemotional traits thought to be antecedents of psychopathy. No structural brain imaging study has examined this subgroup of children. The present study used voxel-based morphometry to compare whole brain grey matter volumes and concentrations of boys with elevated levels of callousunemotional conduct problems and typically developing boys and explored four a priori regions of interest. sMRI scans were collected from 23 boys with elevated levels of callousunemotional conduct problems (mean age 11 years 8 months) and 25 typically developing boys (mean age 11 years 6 months) selected from a community sample of children. Data were analysed using optimized voxel-based morphometry. Study-specific probability maps were created and four a priori regions of interest identified (orbitofrontal, anterior cingulate and anterior insular cortices and amygdala). Both grey matter volume and concentration were examined controlling for cognitive ability and hyperactivityinattention symptoms. Boys with callousunemotional conduct problems, as compared with typically developing boys, presented increased grey matter concentration in the medial orbitofrontal and anterior cingulate cortices, as well as increased grey matter volume and concentration in the temporal lobes bilaterally. These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callousunemotional conduct problems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据