期刊
BRACHYTHERAPY
卷 11, 期 3, 页码 176-180出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brachy.2011.05.005
关键词
Vaginal cancer; Interstitial brachytherapy; 3D HDR; High dose rate
PURPOSE: To evaluate dosimetric and clinical outcomes of three-dimensional (3D) image-based high-dose-rate (HDR) interstitial brachytherapy (HDRB) in patients with vaginal cancers. METHODS AND MATERIALS: Thirty patients with vaginal cancers were treated with HDRB using Syed-Neblett template. CT scan was done after placement of needles for confirmation of placement and treatment planning. The target volume and organs at risk, including clinical target volume (CTV), rectum, bladder, and sigmoid colon, were contoured on CT scans. Twenty-eight (93.3%) patients received external beam radiation therapy at a median 45 (24.0-50.4) Gy in 12-28 fractions, followed by HDRB at 3.75-5.0 Gy per fraction in five fractions. Total doses for CTV and organs at risk from external beam radiation therapy and HDRB were summated and normalized to a biologically equivalent dose of 2 Gy per fraction. RESULTS: Seventeen patients (56.7%) with primary vaginal cancer and 13 patients (43.3%) with recurrent vaginal cancers were treated with 3D HDRB. The mean CTV was 39.3 +/- 25.7 cm(3), and the median tumor diameter was 3.3 (1.3-8.0) cm. The median biologically equivalent dose of 2 Gy per fraction for 2 cc of bladder, rectum, and sigmoid was 55.0, 56.3, 50.0 Gy, respectively. The median D-90 for high-risk CTV was 74.3 (36.3-81.1) Gy. The mean volume receiving 100%, 150%, and 200% of prescribed dose was 90.7 +/- 10.0%, 41.3 +/- 14.6%, and 17.7 +/- 8.3%, respectively. With a median followup of 16.7 months, the respective 1-/2-year locoregional and overall survival rates were 84.4%/78.8% and 82.1%/70.2%, respectively. There were no Grade gastrointestinal complications. Late complications of Grade >= 3 vaginal ulceration and Grade 4 vaginal necrosis were seen in two cases. CONCLUSIONS: Initial results of 3D HDRB using our fractionation schedule in the treatment of vaginal cancers showed good local response with acceptable morbidities. (C) 2012 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据