期刊
DERMATO-ENDOCRINOLOGY
卷 3, 期 1, 页码 23-26出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/derm.3.1.14615
关键词
PPAR; allergic contact dermatitis; atopic dermatitis; psoriasis; skin barrier
类别
资金
- Austrian Science Fund FWF [P 21449] Funding Source: Medline
Peroxisome proliferator-activated receptor (PPAR)-alpha is a fatty acid activated transcription factors that belongs to the nuclear hormone receptor family. Primarily PPAR-alpha serves as a lipid sensor. While PPAR-alpha controls enzymes from the lipid and glucose metabolism in the liver, heart and muscles, PPAR-alpha is also involved in skin homeostasis. PPAR-alpha controls keratinocyte proliferation/differentiation, contributes to wound healing and regulates skin inflammation. PPARalpha activation exerts anti-inflammatory effects in various skin conditions such as irritant and allergic contact dermatitis, atopic dermatitis and UV-induced erythema, rendering investigations into the functions of PPAR-alpha necessary to provide better understandings to treat many inflammatory skin disorders.
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