期刊
CURRENT DIABETES REVIEWS
卷 7, 期 1, 页码 41-49出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157339911794273928
关键词
Obesity; Kidney disease; Adiponectin; Focal sclerosis; Albuminuria
资金
- NIDDK [R01 DK053867, U01DK076133]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK053867, U01DK076133] Funding Source: NIH RePORTER
Obesity is a risk factor for both de novo disease and as a complication of existing chronic kidney disease. Obesity related disease is characterized by albuminuria, glomerulomegaly and secondary focal glomerulosclerosis. Traditionally altered renal hemodynamics causing hyperfiltration and upregulated renin angiotensin system have been associated with these changes. Recently identified circulating factors produced by fat stores such as adiponectin, leptin and inflammatory markers have shown to directly affect the cells in the renal glomeruli and cause pathological changes. Weight loss, blockade of the renin angiotensin system and restoration of adipokine levels may be beneficial to ameliorate the progression of obesity related disease.
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