期刊
JOURNAL OF SKIN CANCER
卷 2011, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2011/454157
关键词
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类别
资金
- Canadian Institutes for Health Research [MOP 86731, MOP 77903]
- Canadian Cancer Society [CCS20485]
- CIHR Frederick Banting
- Charles Best Canada Graduate Scholarship
Arsenic is a potent human carcinogen. Around one hundred million people worldwide have potentially been exposed to this metalloid at concentrations considered unsafe. Exposure occurs generally through drinking water from natural geological sources, making it difficult to control this contamination. Arsenic biotransformation is suspected to have a role in arsenic-related health effects ranging from acute toxicities to development of malignancies associated with chronic exposure. It has been demonstrated that arsenic exhibits preference for induction of squamous cell carcinomas in the human, especially skin and lung cancer. Interestingly, keratins emerge as a relevant factor in this arsenic-related squamous cell-type preference. Additionally, both genomic and epigenomic alterations have been associated with arsenic-driven neoplastic process. Some of these aberrations, as well as changes in other factors such as keratins, could explain the association between arsenic and squamous cell carcinomas in humans.
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