期刊
BONE MARROW TRANSPLANTATION
卷 48, 期 8, 页码 1040-1045出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2013.7
关键词
mesenchymal stromal cell; co-transplantation; umbilical cord blood transplantation; engraftment
资金
- National R&D Program Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea [0520290]
- Korea Health 21R&D Project, Ministry of Health, Welfare and Family affairs, Republic of Korea [0405-DB00-0101-0016]
- Korea Health Promotion Institute [0520290] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Success of umbilical cord blood transplantation (UCBT) has been limited by a high rate of graft failure and delayed hematological recovery. It has been postulated that MSCs have hematopoiesis-supportive properties. Therefore, to overcome the limitation of UCBT, third-party UCB-derived MSCs were co-transplanted in recipients receiving unrelated UCBT. Seven patients received UCB and third-party UCB-MSCs. Hematopoietic recovery and transplantation outcomes were compared with historic controls. There was no acute toxicity associated with the infusion of MSCs. The median day to neutrophil engraftment was 19 days in patients, as compared with 24 days in controls (P = 0.03). The median day of platelet engraftment was 47 days and 57 days in patients and controls, respectively (P = 0.26). In addition, there was no engraftment failure in the MSC group. The incidence of acute and chronic GVHD was comparable between the two groups. However, veno-occlusive disease and TRM did not occur in the MSC group. Third-party UCB-MSCs infusion was safe and feasible. MSCs may also enhance the engraftment of UCBT and prevent rejection. In addition, MSCs may have a role in decreasing TRM. Randomized, controlled trials are required to confirm these results and longer follow-up will determine the effects of MSCs on the risk of relapse.
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