期刊
GUT MICROBES
卷 2, 期 3, 页码 178-182出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.2.3.16107
关键词
gut; microbiome; toll-like receptor 2; adaptation; environment; inflammatory bowel diseases; obesity
资金
- Crohn's and Colitis Foundation of America-Children's Digestive Health and Nutrition Foundation/North American Society of Pediatric Gastroenterology Hepatology and Nutrition (CCFA) [2426]
- Broad Medical Research Program
- Broad Foundation [IBD0252]
- Child Health Research Career Development Agency of the Baylor College of Medicine (NIH) [5K12 HD041648]
- Public Health Service grant [DK56338]
The stunning complexity of the resident microbiota and the intricate pathways of microbial and host interactions provide a massive adaptive capacity for mammals. In this addendum we reflect on our recent publication on Toll-like receptor 2 deficiency related colonic mucosal epigenetic, immunologic and microbiomic changes. Our findings underscored the tremendous flexibility of the gut and its microbiota. This flexibility can provide means to overcome significant environmental or genetic challenges. In the meantime, the challenged intestinal system may become vulnerable to otherwise tolerable insults. In such instances, the fine-tuned mutualistic balance between the gut and its microflora may collapse leading to dysbiosis and disease. The ultimate challenge for biomedical research in these cases is to find optimal means for the restoration and maintenance of healthy host physiology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据