期刊
BONE MARROW TRANSPLANTATION
卷 46, 期 4, 页码 485-501出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2011.11
关键词
hematopoietic SCT; stem cell source; Europe; transplant rates; indication; practice guidelines
资金
- Amgen Europe
- Celegene International SARL
- Genzyme
- Gilead Sciences UK
- Miltenyl Biotec GmbH
- Schering-Plough
- F Hoffmann-La Roche Ltd
- CaridianBCT Europe NV
- Cephalon
- Fresenius Biotech GmbH
- Therakos
- Gentium SpA
- Alexion Europe
- Chugai Sanofi Aventis
- Merck Sharp and Dohme
- Novartis
- Pfizer
- Pierre Fabre Medicament
- Hospira
- Swiss National Research Foundation [LSH-2002-2.2.0-3]
Six hundred and twenty-four centers from 43 countries reported a total of 31 322 hematopoietic SCT (HSCT) to this 2009 European Group for Blood and Marrow Transplantation (EBMT) survey with 28 033 first transplants (41% allogeneic, 59% autologous). The main indications were leukemias (31%; 92% allogeneic), lymphomas (58%; 12% allogeneic), solid tumors (5%; 6% allogeneic) and non-malignant disorders (6%; 88% allogeneic). There were more unrelated than HLA-identical sibling donors (51 vs 43%) for allogeneic HSCT; the proportion of peripheral blood as stem cell source was 99% for autologous and 71% for allogeneic HSCT. Allogeneic and autologous HSCT continued to increase by about 1000 HSCT per year since 2004. Patterns of increase were distinct and different. In a trend analysis, allogeneic HSCT increased in all World Bank Categories (P = 0.01, two sided; all categories), autologous HSCT increased in middle-(P = 0.01, two sided) and low-income (P = 0.01, two sided) countries. EBMT practice guidelines appeared to have an impact on trend, with a clear increase in absolute numbers within the categories 'standard' and 'clinical option' for both allogeneic and autologous HSCT (P = 0.01, two sided; for both allogeneic and autologous HSCT) and a clear decrease in autologous HSCT for the 'developmental' and 'generally not recommended' indications (P = 0.01, two sided). These data illustrate the status and trends of HST in Europe. Bone Marrow Transplantation (2011) 46, 485-501; doi:10.1038/bmt.2011.11; published online 28 February 2011
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