期刊
BONE MARROW TRANSPLANTATION
卷 45, 期 1, 页码 123-127出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2009.114
关键词
palonosetron; 5-HT3 antagonist; autologous stem cell transplantation; antiemetics; chemotherapy-induced nausea and vomiting (CINV)
The aim of this study was to determine the efficacy of palonosetron combined with dexamethasone in prevention of chemotherapy (CT)-induced nausea and vomiting (CINV) in patients receiving high-dose (HD)-CT with auto-SCT, and the efficacy of a second dose of palonosetron in treating breakthrough emesis. One hundred thirty-four patients treated with HD-CT and auto-SCT for hematologic malignancies received palonosetron as prophylaxis for CINV on the first day of conditioning; patients were also administered dexamethasone throughout the entire period of conditioning. If breakthrough emesis occurred, a second dose of palonosetron was administered at 72 h after the first administration. Complete response and complete protection were observed in 36 and 26% of patients, respectively. One-half of the patients, re-treated with palonosetron for breakthrough emesis, were successfully rescued. Treatment with palonosetron plus dexamethasone seems to be encouraging in terms of prophylaxis of CINV and treatment of breakthrough emesis in the setting of HD-CT. Bone Marrow Transplantation (2010) 45, 123-127; doi: 10.1038/bmt.2009.114; published online 1 June 2009
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