期刊
BONE
卷 58, 期 -, 页码 55-58出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2013.10.007
关键词
Brown adipose tissue (BAT); Bone; Structure; Muscle; Fat
资金
- National Institutes of Health [R24 DK084970]
Purpose: Recent studies suggest a link between brown adipose tissue (BAT) and bone. The purpose of our study was to investigate the effects of BAT on femoral bone structure. Materials and methods: We studied 105 patients (19 m, 86 f. mean age 45.5 +/- 16.1 years) who underwent F18-FDG positron emission tomography/computed tomography (PET/CT) for benign etiologies (n = 20) or follow-up of successfully treated malignancies (n = 85); mean time between PET/CT and last form of treatment was 14.8 +/- 18.0 months. BAT volume by PET/CT; femoral bone structure by CT (total femoral cross-sectional area (CSA), cortical CSA); and thigh muscle CSA and thigh subcutaneous fat CSA by CT was assessed. Results: There were positive correlations between BAT volume and total femoral CSA and cortical CSA, independent of age, BMI and history of malignancy (p < 0.05). BAT volume correlated positively with thigh muscle CSA and thigh fat CSA (p < 0.05). When total femoral CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables in a forward stepwise regression model, BAT volume was the only predictor of total femoral CSA. When femoral cortical CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables, BAT volume was the only predictor of femoral cortical CSA. Conclusion: BAT volume is a positive predictor of femoral bone structure and correlates positively with thigh muscle and subcutaneous fat, possibly mediated by muscle. These results provide further evidence of a positive effect of BAT on bone. (C) 2013 Elsevier Inc. All rights reserved.
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