期刊
BONE
卷 54, 期 2, 页码 272-278出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2012.09.017
关键词
Osteocytes; Apoptosis; Autophagy; Involutional osteoporosis; Post-menopausal osteoporosis; Steroid-induced osteoporosis; Osteogenesis imperfecta; Anti-resorptive therapies
资金
- National Institutes of Health [P01 AG13918]
- Department of Veterans Affairs
- University of Arkansas for Medical Sciences
Osteocytes are long-lived and far more numerous than the short-lived osteoblasts and osteoclasts. Immured within the lacunar-canalicular system and mineralized matrix, osteocytes are ideally located throughout the bone to detect the need for, and accordingly choreograph, the bone regeneration process by independently controlling rate limiting steps of bone resorption and formation. Consistent with this role, emerging evidence indicates that signals arising from apoptotic and old/or dysfunctional osteocytes are seminal culprits in the pathogenesis of involutional, post-menopausal, steroid-, and immobilization-induced osteoporosis. Osteocyte-originated signals may also contribute to the increased bone fragility associated with bone matrix disorders like osteogenesis imperfecta, and perhaps the rapid reversal of bone turnover above baseline following discontinuation of anti-resorptive treatments, like denosumab. This article is part of a Special Issue entitled The Osteocyte. Published by Elsevier Inc.
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