期刊
BONE
卷 54, 期 2, 页码 196-204出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2012.11.016
关键词
Bone; Mechanotransduction; Mechanosensation; Osteocytes; Primary cilia
资金
- NIH grants [AR45156, AR59038]
- New York State Stem Cell Grant [N089-210]
- NSF Graduate Research Fellowship
The primary cilium is a solitary, immotile microtubule-based extension present on nearly every mammalian cell. This organelle has established mechanosensory roles in several contexts including kidney, liver, and the embryonic node. Mechanical load deflects the cilium, triggering biochemical responses. Defects in cilium function have been associated with numerous human diseases. Recent research has implicated the primary cilium as a mechanosensor in bone. In this review, we discuss the cilium, the growing evidence for its mechanosensory role in bone, and areas of future study. This article is part of a Special Issue entitled The Osteocyte. (C) 2012 Elsevier Inc. All rights reserved.
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