期刊
ADVANCES IN VIROLOGY
卷 2011, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2011/129134
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类别
资金
- National 863 program of China [2007AA02Z464, 2007AA02Z463]
- China-Australia Health and HIV/AIDS Facility program [EID07]
- Chinese Center for Disease Control and Prevention [2009ZX10004-101, 2009ZX10004-202, 2008ZX10004-001, 2008ZX10004-002, 2008ZX10004-004]
- State Key Laboratory for Genetic Engineering and Molecular Virology
The human coronaviruses (HCoVs) HCoV-NL63 and HCoV-HKU1 are two recently discovered coronaviruses that circulate widely and are associated with acute respiratory infections (ARI). We detected HCoV-NL63 and HCoV-HKU1 in specimens collected from May 2008 to March 2010 from patients with ARI aged <7.75 years of age attending the Beijing Children's Hospital. Thirty-two (8.4%) and 57 (14.9%) of 382 specimens tested positive for HCoV-NL63 and HCoV-HKU1, respectively, by real-time RT-PCR. Use of a Luminex xTAG RVP Fast kit showed that coinfection with respiratory syncytial virus and parainfluenza 3 virus was common among patients infected with either virus type. InHCoV-HKU1-infected patients, the predominant clinical symptoms were cough, fever, and expectoration. In HCoV-NL63-infected patients they were cough, fever, and rhinorrhea. Phylogenetic studies showed that the HCoV-HKU1 nucleoprotein gene was relatively conserved compared to NCBI reference sequences, while the 1ab gene of HCoV-NL63 showed more variation.
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