期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
卷 1, 期 1, 页码 103-112出版社
KARGER
DOI: 10.1159/000327518
关键词
Alzheimer's disease; Cohort studies; Dementia; Diet; Population-based studies; Risk factors
资金
- Kuopio University Hospital [5772720, 5772709]
- Academy of Finland [103334, 206951, 120676]
- EU [QLK-2002-172, 211696]
- Swedish Council for Working Life and Social Research
- Finnish Cultural Foundation
- Foundation of Juho Vainio
- Yrjo Jahnsson Foundation
Aim: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD). Methods: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components. Results: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders. Conclusions: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible. Copyright (C) 2011 S. Karger AG, Basel
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