期刊
BONE
卷 51, 期 4, 页码 680-687出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2012.07.019
关键词
Athletes; Adolescents; Bone strength; Stiffness; Failure load
资金
- NCRR NIH HHS [UL1 RR025758, 1 UL1 RR025758-01, S10 RR 023405] Funding Source: Medline
- NICHD NIH HHS [R01 HD060827, 1 R01 HD060827-01A1] Funding Source: Medline
- NIDDK NIH HHS [P30 DK040561] Funding Source: Medline
Context: Lower bone density in young amenorrheic athletes (AA) compared to eumenorrheic athletes (EA) and non-athletes may increase fracture risk during a critical time of bone accrual. Finite element analysis (FEA) is a unique tool to estimate bone strength in vivo, and the contribution of cortical microstructure to bone strength in young athletes is not well understood. Objective: We hypothesized that FEA-estimated stiffness and failure load are impaired in AA at the distal radius and tibia compared to EA and non-athletes despite weight-bearing exercise. Design and setting: Cross-sectional study; Clinical Research Center Subjects: 34 female endurance athletes involved in weight-bearing sports (17 AA, 17 EA) and 16 non-athletes (14-21 years) of comparable age, maturity and BMI Outcome measures: We used HR-pQCT images to assess cortical microarchitecture and FEA to estimate bone stiffness and failure load. Results: Cortical perimeter, porosity and trabecular area at the weight-bearing tibia were greater in both groups of athletes than non-athletes, whereas the ratio (%) of cortical to total area was lowest in AA. Despite greater cortical porosity in EA, estimated tibial stiffness and failure load was higher than in non-athletes. However, this advantage was lost in AA. At the non-weight-bearing radius, failure load and stiffness were lower in AA than non-athletes. After controlling for lean mass and menarchal age, athletic status accounted for 5-9% of the variability in stiffness and failure load, menarchal age for 8-23%, and lean mass for 12-37%. Conclusion: AA have lower FEA-estimated bone strength at the distal radius than non-athletes, and lose the advantage of weight-bearing exercise seen in EA at the distal tibia. (C) 2012 Elsevier Inc. All rights reserved.
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