期刊
CURRENT HYPERTENSION REVIEWS
卷 7, 期 4, 页码 228-239出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340211799304761
关键词
Adrenomedullin; angiogenesis; endothelial; lymphangiogenesis; mouse model; permeability; CLR; RAMPs
资金
- NIH [HL091973, HD060860]
- Burroughs Wellcome Fund
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD060860] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL091973] Funding Source: NIH RePORTER
Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.
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