期刊
CURRENT RADIOPHARMACEUTICALS
卷 4, 期 3, 页码 261-265出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1874471011104030261
关键词
Alpha-particles; dosimetry; modelling; microdosimetry
资金
- NCI NIH HHS [P30 CA006973] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA006973] Funding Source: NIH RePORTER
As a consequence of the high potency and short range of alpha-particles, radiopharmaceutical therapy with alpha- particle emitting radionuclides is a promising treatment approach that is under active pre-clinical and clinical investigation. To understand and predict the biological effects of alpha-particle radiopharmaceuticals, dosimetry is required at the micro or multi-cellular scale level. At such a scale, highly non-uniform irradiation of the target volume may be expected and the utility of a single absorbed dose value to predict biological effects comes into question. It is not currently possible to measure the pharmacokinetic input required for micro scale dosimetry in humans. Accordingly, pre-clinical studies are required to provide the pharmacokinetic data for dosimetry calculations. The translation of animal data to the human requires a pharmacokinetic model that links macro-and micro-scale pharmacokinetics thereby enabling the extrapolation of micro-scale kinetics from macroscopic measurements. These considerations along with a discussion of the appropriate physical quantity and related units for alpha-particle radiopharmaceutical therapy are examined in this review.
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