期刊
BONE
卷 47, 期 2, 页码 212-218出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2010.05.030
关键词
Bioactive glass; Bone substitute; Osteomyelitis; Antibacterial; Osteoconductive
Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results. (C) 2010 Elsevier Inc. All rights reserved.
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