期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 42, 期 8, 页码 703-710出版社
WILEY
DOI: 10.1111/jcpe.12437
关键词
epidemiology; genome-wide association studies; Korean; periodontitis; single-nucleotide polymorphisms
资金
- Korea Center for Disease Control and Prevention, Republic of Korea [4845-301, 4851-302, 4851-307, KBP-2014-15]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2013-062881]
- NRF Grant, through the Oromaxillofacial Dysfunction Research Center for the Elderly [2014-050477]
AimThis study aims to locate the genes related to periodontitis through genome-wide association study (GWAS) in Korean population. MethodsTotal of 677 adults aged 44-88years were recruited from the Yangpyeong cohort in Korea. The participants did not have self-reported metabolic diseases, cardiovascular diseases or cancer. Periodontitis was assessed using alveolar bone loss from a digital panoramic radiograph and classified into three groups: normal to mild, moderate and severe periodontitis. DNA from blood samples were genotyped using the Illumina Human 1M-duo Beadchip. Multivariable logistic regression analysis in PLINK was applied to examine the single-nucleotide polymorphisms (SNPs) related to periodontitis after controlling for various confounders. ResultsAssociations of three SNPs suggested TENM2 (rs4242220) and LDLRAD4 (rs12969041, rs2027756) as putative risk genes of chronic periodontitis (p-values <1x10(-5)). The odds ratio [95% confidence interval (CI)] of TENM2 was 0.53 (0.40-0.70) for moderate periodontitis and that of LDLRAD4 was 2.86 (1.92-4.27) for severe periodontitis. Two nonsynonymous SNPs of protein coding region and seven SNPs selected from previous reports showed nominal association. ConclusionOur GWAS supports a previously reported gene of TENM2 and newly suggests LDLRAD4. These two genes' role on lipid metabolism may play a part in the molecular aetiology of periodontitis.
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