期刊
BMC SYSTEMS BIOLOGY
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1752-0509-7-139
关键词
Network pharmacology; Drug mode of action; Drug repositioning
资金
- Fondazione Telethon grant [TGM11SB1]
- EU [289434]
Network-based drug discovery aims at harnessing the power of networks to investigate the mechanism of action of existing drugs, or new molecules, in order to identify innovative therapeutic treatments. In this review, we describe some of the most recent advances in the field of network pharmacology, starting with approaches relying on computational models of transcriptional networks, then moving to protein and signaling network models and concluding with drug networks. These networks are derived from different sources of experimental data, or literature-based analysis, and provide a complementary view of drug mode of action. Molecular and drug networks are powerful integrated computational and experimental approaches that will likely speed up and improve the drug discovery process, once fully integrated into the academic and industrial drug discovery pipeline.
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