期刊
ARKIVOC
卷 -, 期 -, 页码 220-228出版社
ARKAT USA INC
DOI: 10.3998/ark.5550190.0013.919
关键词
1,2,4-Oxadiazole; phidianidine; chemical synthesis
资金
- PRIN-MIUR Project Prodotti naturali da molluschi opistobranchi: identificazione di nuovi lead compounds per lo sviluppo di farmaci antitumorali
Phidianidine B (1), a natural 1,2,4-oxadiazole linking both an indole system and an aminoalkyl guanidine group that has been recently reported from a marine mollusk, has been synthesized in seven steps (14% total yield). The synthetic procedure, which is based on the coupling of 3-indolacetic acid methyl ester and the amino-alkyl hydroxy guanidine intermediate 2, opportunely prepared, is of general application and allows the synthesis of analogues with either different alkyl chain length or substitution on the indole ring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据